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Statements Author contributions CL and GK participated in the design, writing, and final corrections of the manuscript

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Recommended Cycling Schedules Option 1: Quarterly Protocol 10-day cycle every 3 months 4 cycles per year 2.5-month breaks between cycles Option 2: Bi-Annual Protocol 20-day cycle twice yearly Spring and fall timing common 5-6 month breaks between cycles Option 3: Intensive Initial Protocol First year: 4 cycles (quarterly) Subsequent years: 2 cycles (bi-annual) Maintenance approach after initial optimization Sample Annual Calendar Factors That Influence Optimal Epithalon Dosage Individual variation means that the "perfect" epithalon peptide dosage may differ from person to person